Journal of Research in Ecology
JRE
Ecology
http://ecologyresearch.info/
0
2319-1546
2319-1554
en
2018
09
26
6
2
online
1
fulltext
en
Study of changes using biochemical markers in albino mice after acute exposure to acetamiprid
Ecology
Original Research
The present study aimed to investigate the acetamiprid effects on biochemical aspects in albino mice. Thirty albino mice at the age of 6-8 weeks and average weight 25±5 g were divided into three groups each having ten (10) healthy mice. The first group was orally administrated with distilled water while the second and third groups were orally administrated with 50 mg/mL and 100 mg/mL respectively of acetamprid (0.1 mL) daily for one week. LD50 of acetamiprid was measured and found to be 200 mg/kg. The parameters of evaluations included liver function using Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Alkaline Phosphatase (ALP). Lipid profile was analysed using Total Cholesterol (TC), Triglycerides (TG), High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) and Very Low Density Lipoprotein (VLDL). Antioxidant factors such as Superoxide Dismutase (SOD), Malondialdehyde (MDA), Catalase (CAT) and Glutathione Peroxidase (GPx), Calcium ion (ca2+) and Aacetylcholine Esterase (AchE) were also measured. The study suggested that acetamprid 100 mg\mL significantly affected the biochemical component and it was considered to be a toxic dose of acetamiprid in albino mice
Acetamprid, Albino mice, Biochemical markers, Acute toxicity
2192
2200
http://ecologyresearch.info/documents/EC0654.pdf
Salah
Al-Chalabi
Yes
Biotechnology Researches Center, Al-Nahrain University, Baghdad, Iraq
Duha
Zeki
Al-Swefee
No
Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq
Ahmed
Jasim
Mohammed
No
Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq